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                                                                                                                                    1. Liu B, Zhang M,  Chu H, Zhang H, Wu H, Song G, Wang P, Zhao K, Hou J, Wang X, Zhang L, Gao  Chengjiang*. 2016. The ubiquitin E3 ligase TRIM31 promotes aggregation and  activation of the signaling adaptor MAVS through Lys63-linked  polyubiquitination. Nat Immunol. doi: 10.1038/ni.3641. [Epub ahead of  print]  

                                                                                                                                    2. Song H, Liu B, Huai  W, Yu Z, Wang W, Zhao J, Han L, Jiang G, Zhang L, Gao Chengjiang*, Zhao W*.  2016. The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by  promoting proteasomal degradation of NLRP3. Nat Commun. 7:13727.

                                                                                                                                    3. Song G, Liu B, Li Z,  Wu H, Wang P, Zhao K, Jiang G, Zhang L, Gao Chengjiang*. 2016. E3 ubiquitin  ligase RNF128 promotes innate antiviral immunity through K63-linked  ubiquitination of TBK1. Nat Immunol. 17(12):1342-1351.

                                                                                                                                    4. Huai W#, Song H#, Yu  Z, Wang W, Han L, Sakamoto T, Seiki M, Zhang L, Zhang Q, Zhao W*. Mint3  potentiates TLR3/4- and RIG-I-induced IFN-β expression and antiviral immune  responses. Proc Natl Acad Sci USA. 2016; 113(42):11925- 11930.

                                                                                                                                    5. Yan W, Liu X, Ma H,  Zhang H, Song X, Gao L, Liang X, Ma C.* Tim-3 fosters HCC development by  enhancing TGF-β-mediated alternative activation of macrophages.Gut. 2015 Jan 21.  pii: gutjnl-2014-307671. doi: 10.1136/gutjnl-2014-307671. [Epub ahead of  print]

                                                                                                                                    6. Zhang Z, Liang X, Gao  L, Ma H, Liu X, Pan Y, Yan W, Shan H, Wang Z, Chen YH**, Ma C**.TIPE1 induces  apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma  cells. Oncogene. 2015 May 14;34(20):2566-74.

                                                                                                                                    7. Huai W#, Zhao R#,  Song H, Zhao J, Zhang L, Zhang L, Gao C, Han L*, Zhao W*. Aryl hydrocarbon  receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3  transcription. Nat.Commun. 2014; 5:4738.

                                                                                                                                    8.Song X, Zhang X, Wang  X, Zhu F, Guo C, Wang Q, Shi Y, Wang J, Chen Y, Zhang L*. Tumor suppressor gene  Pdcd4 negatively regulates autophagy by inhibiting the expression of  autophagy-related gene Atg5. Autophagy. 2013; 9(5):743-55

                                                                                                                                    9. Wang Q*, Dong Z, Liu  X, Song X, Song Q, Shang Q, Jiang Y, Guo C, Zhang L*. PDCD4 Deficiency Prevents  Diet-Induced Obesity, Adipose Tissue Inflammation and Insulin Resistance.  Diabetes. 2013; 62(12):4132-43

                                                                                                                                    10. Zhang M#, Wang L,  Zhao X, Zhao K, Meng H, Zhao W*, Gao C*. TRAF-interacting protein (TRIP)  negatively regulates IFN-β production and antiviral response by promoting  proteasomal degradatio





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